The highly anticipated second part of The Apothecary Diaries Season 2 is set to premiere on April 4, 2025. Alongside the release date, a brand-new trailer, visual, and theme song artists have been revealed.
New Trailer and Theme Songs
The newly released trailer showcases key moments from the upcoming episodes, giving fans a glimpse of Maomao’s ongoing journey in the imperial palace. It also introduces the new opening theme song “Kusuhiki” (Mysterious) by Mrs. Green Apple and the ending theme song “Hitorigoto” (Soliloquy) by Omoinotake.
Previously, The Apothecary Diaries featured Lilas Ikuta performing “Hyakkaryōran” (Splendid Bounty) as the first season’s opening, while Dai Hirai performed the ending theme “Shiawase no Recipe” (The Recipe for Happiness).
Season Overview and What to Expect
Cour 1 Overiew
Apothecary Diaries Season 2 Cour 1 sees Maomao officially working under Jinshi in the inner palace, bringing her closer to courtly intrigue. She continues to solve medical mysteries and unusual ailments affecting the palace inhabitants, relying on her sharp intellect and knowledge of poisons.
A key storyline involves Maomao investigating a recurring mysterious illness, uncovering old secrets and potential conspiracies within the imperial court through her keen observations.
© 日向夏・イマジカインフォス／「薬屋のひとりごと」製作委員会
Jinshi’s interest in Maomao deepens, and their interactions become more nuanced, showing his respect for her abilities despite his teasing. Their dynamic hints at a growing connection.
The season introduces new characters and further develops existing ones, showcasing the struggles and ambitions of the other consorts. Maomao’s professional interactions sometimes lead to unexpected alliances.
Overall, the first cour maintains its blend of intricate mystery-solving, historical setting, and subtle character development, with Maomao using her medical knowledge and wit to unravel secrets while her relationship with Jinshi slowly evolves amidst court intrigue.
What to Expect in Apothecary diaries season 2 cour 2
In the second season, Maomao’s intelligence continues to attract powerful figures, including the enigmatic Jinshi, leading her deeper into the complex web of politics, deception, and danger that surrounds the imperial court.
Cast and Production Details
The anime is produced by TOHO Animation and OLM, with Norihiro Naganuma (The Ancient Magus’ Bride Season 1) as director and script supervisor. Other key staff members include:
- Akinori Fudesaka – Assistant Director
- Yukiko Nakatani – Character Designer
- Shōji Hata – Sound Director
- Satoru Kousaki, Kevin Penkin, and Arisa Okehazama – Music Composition
New cast members include:
- Asami Seto as Shisui
- Lynn as Ayla
- Yumi Hara as Aylin
The Apothecary Diaries Season 2 Cour 2 Release Date
- The Apothecary Diaries Season 2 Part 2 will premiere on April 4, 2025.
- The anime will continue its two-cour format on Nippon TV’s FRIDAY ANIME NIGHT programming block.
- Crunchyroll will stream the season, including an English dub.
Where to Watch The Apothecary Diaries
All episodes of The Apothecary Diaries (including previous seasons) are available for streaming on Crunchyroll and Prime Video. The English manga adaptation is published by Square Enix Manga & Books, with the light novels released in English by J-Novel Club.
