Which are the best anime in America? Ever since Animation became popular in Japan, the rise has been spectacular. Anime series have become popular in Western countries since the early 80s. Anime series are primarily set in fictional and magical worlds. Some anime series are set in Japan, America, and England. Anime in America explores the culture, traditions, and popular spots. Let us see the best anime that takes place in the USA.
91 Days
- Genre – Crime Drama
- Episodes – 13
- Streaming Networks – Amazon Prime Video, Crunchyroll
- IMDb Rating – 7.6/10
91 Days anime takes place in the USA in the early 1930s during the Prohibition Period. In the series, the Italian mafia dominates America with the sales of liquor. 91 Days takes place in the fictional city Lawless and it focuses on the journey of Angelo Lagusa, who is a victim of a crime. His family gets murdered by a Mafia and Lagusa impersonates another person’s identity to enter the Vincent Vanetti mafia family to take revenge. Lagusa has 91 days to complete his revenge against the Vanetti mafia. It blends action, revenge, and emotions.

Baccano!
- Genre – Mystery, Supernatural
- Episodes –
- Streaming Networks – Amazon Prime Video
- IMDb Rating – 8.6/10
Baccano! is a riveting anime set in the USA. It is one of the best anime that takes place in major locations of America like Chicago, New York, and Alcatraz. It is set in the 1930s that follows the journey of a group of people including a scientist who search for a powerful elixir that was crafted in 1711 by alchemists with the help of a demon. As the story moves, a group of mafia get involved in the case and the protagonist manages to get the elixir that increases the lifespan of a person.

JoJo’s Bizarre Adventure
- Genre – Adventure, Action, Supernatural
- Streaming Networks – Crunchyroll, Netflix, Amazon Prime Video
- Imdb Rating – 8.5/10
JoJo’s Bizarre Adventure is a series of action thrillers that explores many locations in the USA. It has been hailed as one of the best anime that’s set in America. It is all about the members of the Joestar family who have special skills. The goal of the Joestar family is to hunt down monsters and supernatural entities. JoJo’s Bizarre Adventure is set in different eras and timelines. Every generation of the Joestar family embarks on a mission against their rivals. JoJo’s Bizarre Adventure original manga series sold more than 130 million copies and it is one of the highest-selling manga of all time. The story takes place in Chicago, Florida, East Coast Regions, and New York City.

Banana Fish
- Genre – Thriller, Gangster, Drama
- Episodes – 24
- Streaming Networks – Amazon Prime Video, Netflix
- IMDb Rating – 8.1/10
Banana Fish is a popular anime set in america. It explores the urban lifestyle theme and is inspired by street gangsters of the USA in the early 1980s. Banana Fish is all about Ash Lynx, a teenage gang leader from New York. Lynx’s brother Griffin is a Vietnam war veteran, but he is in a vegetative state after an incident. Lynx left the mafia and formed his own gang. His brother said the words, Banana Fish, and it has become a mystery since the Iraq war. Ash Lynx meets new characters at a bar who get abducted by his former Mafia leader, Dino. Ash embarks on a journey to save the photographers and also find the mystery behind the Banana Fish.

Appare-Ranman!
- Genre – Comedy, Adventure
- Episodes – 13
- Streaming Networks – Crunchyroll, Amazon Prime Video
- IMDb Rating – 6.7/10
Appare-Ranman! starts in Japan during the Meiji Era. Appare Sorano, the second son of a merchant family, is an inventor who loves steamships. One day, Sorano decides to travel across the world and he decides to shift out of Japan. When Sorano begins his journey, one of the samurai follows him and both are stranded in the sea. They spot a steamship that also takes them to Los Angeles. Appare Sorano doesn’t have money, but he participates in the “Trans-America Wild Race” and crafts a custom automobile. The samurai completes a mission and earns bucks. As the story moves, the men from Japan fight against the bandits and rivals of America. It follows their journey in Los Angeles in the late 19th century.
Red Garden
- Genre – Psychological Thriller, Horror
- Episodes – 22
- Streaming Networks – Crunchyroll, Amazon Prime Video
- IMDb Rating – 6.6/10
Red Garden is an intriguing mystery horror thriller anime series set in America. The Red Garden series follows the journey of four girls Kate, Rachel, Rose, and Claire who study at a high school in New York City. One day, when the girls wake up in the morning, they forget everything. The girls’ friend is murdered and all 4 girls are taken to a strange place by a butterfly. The girls meet their friend in a new avatar and the demon instructs everyone to work for the Animus organization to overcome the curse. As the story moves, the girls experience strange incidents and they meet new characters in the dark world. Red Garden is one of the best anime set in the USA in the mystery thriller genre.

Great Pretender
- Genre – Crime, Heist, Comedy
- Episodes – 23
- Streaming Networks – Netflix
- IMDb Rating – 7.8/10
Great Pretender is a heist action anime. It is inspired by real-life events in the USA and has Con Artists in the lead role. It follows the journey of Con Artists from America who engage in a battle to prove their skills. Makoto Edamura, a member of the Edamura family gets involved in crime activities like stealing and scamming. One day, Edamura steals from a tourist, but it is a trap set by the tourist to expose Makoto Edamura. Makoto Edamura also finds the tourist is a conman and the duo move to Los Angeles. Makoto Edamura dreams of becoming the greatest Conman and Swindler in Japan. The con artists play a game and target the mafia boss who lives on the West Coast.

Gunsmith Cats
- Genre – Crime, Girls with guns
- Episodes – 3 (ONA)
- Streaming Networks – Amazon Prime Video
- IMDb Rating – 7.2/10
Gunsmith Cats has been a classic anime even after 2 decades. It is an incredible crime thriller that explores the underworld mafia in America. The story of Gunsmith Cats is set in Chicago and it follows the journey of two girls who are talented bounty hunters. The girls own a firearm store and are popular among gangsters. As the story moves, a mafia leader threatens the girls to work on a new case and the girls eventually agree. When the girls are involved in the new case, they are targeted by another assassin. In the end, it is all about the girls of the Gunsmith Cats shop and their enemies. The riveting screenplay makes Gunsmith Cats one of the top-rated anime set in the USA.

Blood Blockade Battlefront
- Genre – Sci-fi, Urban Fantasy
- Episodes – 26
- Streaming Networks – Crunchyroll, Amazon Prime Video, Netflix
- IMDb Rating – 7.2/10
Blood Blockade Battlefront is an amazing sci-fi anime that takes place in and around New York City. Libra is the most dangerous crime organization in Hellsalem’s Lot, a fictional American city. Vampires, Monkeys, and Monsters rule Hellsalem’s Lot. Humans were trapped inside the area after a gateway was opened. One day, Leonardo Watch, an aspiring photographer visits the place and he finds the mystery of the organization. In the end, the young boy is the only hope for the people of the Libra who lose their lives to monsters.

Cyberpunk: Edgerunners
- Genre – Cyberpunk
- Episodes – 10 (ONA)
- Streaming Networks – Netflix
- IMDb Rating – 8.3/10
Based on the Cyberpunk 2077 video game, Cyberpunk Edgerunners is another anime that takes place in the USA. It is set in the future world of California in 2076. The story is set in the fictional Night City which takes us through the lives of the gangsters of the American Underworld. David Martinez, the young boy, plays the lead role in a dystopian world that is dominated by technology and crime. The Street Kid becomes an Edgerunner, a mercenary outlaw and cyberpunk. He was a member of the Arasaka Academy, but he was expelled after an incident. David Martinez’s goal is to reach the top of the Arasaka security corporation and he uses his skills to fulfill his mother’s wishes.